Prevalence of Human Polyomavirus BK Virus in Prostate Cancer Patients and Benign Prostatic Hyperplasia: A Cross-sectional Study on Prostate Patients Referred to Imam Khomeini Hospital in Ahvaz Between 2015 and 2017

Background: Human polyomavirus BK virus (BKV) belongs to the Polyomaviridae family and seems be a drastic in prostate cancer (PCa) etiology. induces oncogenesis via expression of large tumor antigen (LTAg) small (stAg). Also, BKV infection play an essential role development. Objectives: In this study was aimed prevalence benign cancerous tissues. Methods: study, 100 formalin-fixed paraffin-embedded tissues PCa specimens prostatic hyperplasia (BPH) were collected. The DNA extracted from tissue samples, investigated using semi-nested polymerase chain reaction (PCR). MEGA 6.0 software used for phylogenetic analysis assemble viral genome. A tree constructed by neighbor-joining with 1,000 replicates bootstrap resampling test. Results: found 66% (33/50) patients 36% (18/50) (P = 0.003). frequency different classes Gleason score (5 - 10) not significant (0.094). distribution among age groups 0.086). Conclusions: High detected compared BPH 0.003), coexistence confirmed 51% (51/100) which subtype 1 infection.